On the Development of Health-Based Ventilation Guidelines : Principles and Framework

This paper summarizes the results of HealthVent project. It had an aim to develop health-based ventilation guidelines and through this process contribute to advance indoor air quality (IAQ) policies and guidelines. A framework that allows determining ventilation requirements in public and residential buildings based on the health requirements is proposed. The framework is based on three principles: 1. Criteria for permissible concentrations of specific air pollutants set by health authorities have to be respected; 2. Ventilation must be preceded by source control strategies that have been duly adopted to improve IAQ; 3. Base ventilation must always be secured to remove occupant emissions (bio-effluents). The air quality guidelines defined by the World Health Organization (WHO) outside air are used as the reference for determining permissible levels of the indoor air pollutants based on the principle that there is only one air. It is proposed that base ventilation should be set at 4 L/s per person; higher rates are to be used only if WHO guidelines are not followed. Implementation of the framework requires technical guidelines, directives and other legislation. Studies are also needed to examine the effectiveness of the approach and to validate its use. It is estimated that implementing the framework would bring considerable reduction in the burden of disease associated with inadequate IAQ

an ISES Europe statement

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Current EU research activities on combined exposure to multiple chemicals

Humans and wildlife are exposed to an intractably large number of different combinations of chemicals via food, water, air, consumer products, and other media and sources. This raises concerns about their impact on public and environmental health. The risk assessment of chemicals for regulatory purposes mainly relies on the assessment of individual chemicals. If exposure to multiple chemicals is considered in a legislative framework, it is usually limited to chemicals falling within this framework and co-exposure to chemicals that are covered by a different regulatory framework is often neglected. Methodologies and guidance for assessing risks from combined exposure to multiple chemicals have been developed for different regulatory sectors, however, a harmonised, consistent approach for performing mixture risk assessments and management across different regulatory sectors is lacking. At the time of this publication, several EU research projects are running, funded by the current European Research and Innovation Programme Horizon 2020 or the Seventh Framework Programme. They aim at addressing knowledge gaps and developing methodologies to better assess chemical mixtures, by generating and making available internal and external exposure data, developing models for exposure assessment, developing tools for in silico and in vitro effect assessment to be applied in a tiered framework and for grouping of chemicals, as well as developing joint epidemiological-toxicological approaches for mixture risk assessment and for prioritising mixtures of concern. The projects EDC-MixRisk, EuroMix, EUToxRisk, HBM4EU and SOLUTIONS have started an exchange between the consortia, European Commission Services and EU Agencies, in order to identify where new methodologies have become available and where remaining gaps need to be further addressed. This paper maps how the different projects contribute to the data needs and assessment methodologies and identifies remaining challenges to be further addressed for the assessment of chemical mixtures.European Union's Seventh Framework Programme for research, technological development and demonstration

The Index-pm project : health risks from exposure to indoor particulate matter

This article illustrates the methods and findings of assessing the health risks of exposure to indoor particulate matter in the frame of the European INDEX-PM project [12]. The evaluation was performed by taking into account all sources and types of indoor particulate matter, and distinguishing it to particulate matter (PM) from outdoor origin, from indoor combustion, environmental tobacco smoke, indoor air particles of biological origin, indoor resuspended mineral dust particles, semi-volatile organic compounds, as well as secondary particles generated by indoor air chemistry. It comprises an outline of a state-of-the-art review of existing exposure and doseresponse data of indoor PM and focuses at deriving general and by-source risk characterisation and risk management options for reducing potential health effects associated with exposure to indoor PM